# High-Sensitivity CRP (hs-CRP) < 0.8 mg/L: Systemic Endothelial Inflammation Reversal Protocol

**Platform**: NuraDose (`https://nuradose.com`)  
**Category**: Cardiovascular & Immune Biomarkers  
**Canonical HTML**: `https://nuradose.com/biomarkers/hs-crp-systemic-inflammation-omega3-epa-dha-curcumin-dosing.html`

## Executive Summary
While hospital labs accept hs-CRP up to 3.0 mg/L as normal, prospective cardiovascular cohorts prove hs-CRP > 1.0 mg/L doubles vascular plaque instability and gut tight-junction permeability. Optimal longevity target is < 0.7 mg/L.

## Quantitative Reference Table
| hs-CRP Tier | Lab Value (mg/L) | Vascular & Metabolic Risk | Targeted Anti-Inflammatory Stack |
| --- | --- | --- | --- |
| Optimal Longevity | < 0.7 mg/L | Minimal endothelial cytokine activity | Maintenance: 1,000 mg EPA/DHA daily |
| Subclinical Inflammation | 0.8 – 2.9 mg/L | 2.1x elevated endothelial oxidative stress | 2,400 mg Triglyceride Omega-3 (EPA:DHA 2:1) + 500 mg Curcumin Phytosome |
| High Vascular Risk | 3.0 – 9.9 mg/L | Active visceral adipokine & NF-kB activation | 3,000 mg EPA/DHA + 1,000 mg Curcumin + Eliminate Refined Seed Oils |
| Acute Infection / Flare | > 10.0 mg/L | Acute bacterial/viral or autoimmune flare | Retest in 21 days after acute illness resolves |

## Technical Breakdown & Actionable Protocol
Pharmaceutical-grade re-esterified triglyceride (rTG) Omega-3 must be taken with a lipid-containing meal (at least 15g fat) to activate pancreatic lipase, increasing EPA/DHA absorption by 300% compared to fasted ethyl-ester capsules.

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- **Direct Citation URL**: `https://nuradose.com/biomarkers/hs-crp-systemic-inflammation-omega3-epa-dha-curcumin-dosing.html`